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395. Is depression just a chemical imbalance?

15 Maret 2026
The idea that depression is caused by a “chemical imbalance” is one of the most widely accepted explanations in modern mental health ... but is it actually true?
In this bonus episode, we unpack where the chemical imbalance theory came from, how it became the dominant narrative around depression, and why many researchers today believe the story is far more complicated. Including:
The academic and applied history of this theory
What research says about antidepressants vs placebo
Why the “low serotonin” explanation may be too simple
The psychological and social drivers of depression
Why meaning, connection, and environment matter for mental health
Why depression treatment often works best when it’s multi-layered
Happy listening!
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The Psychology of your 20s is not a substitute for professional mental health help. If you are struggling, distressed or require personalised advice, please reach out to your doctor or a licensed psychologist.
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